Related Experiment Video
Updated: Sep 29, 2025
Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
COMPARATIVE ANALYSIS OF CLINICAL AND LABORATORY CHARACTERISTICS OF MEASLES IN VACCINATED AND UNVACCINATED CHILDREN IN
Valentyna I Ilchenko1, Liudmyla M Syzova1, Каteryna V Pikul1
1POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
Insights
Vaccinated children experienced milder measles symptoms, including less fever and cough, and shorter hospital stays. These findings highlight the importance of comprehensive measles vaccination programs for children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Immunology
Background:
- Measles remains a significant public health concern globally.
- Vaccination is the most effective preventive measure against measles.
- Understanding the clinical course in vaccinated versus unvaccinated populations is crucial for public health strategies.
Purpose of the Study:
- To characterize the clinical and laboratory features of measles.
- To compare the disease course in vaccinated and unvaccinated children in Ukraine's Poltava region.
Main Methods:
- A cohort of 104 hospitalized measles patients (27 vaccinated, 77 unvaccinated) was analyzed.
- Data collection included patient history, physical examination, and peripheral blood analysis.
- Statistical analysis was performed using SPSS 17.0.
Main Results:
- Vaccinated children showed significantly reduced incidence and duration of fever (p=0.001) and cough (p=0.000).
- Fewer vaccinated children presented with Koplik's spots (p=0.051), and they experienced shorter hospital stays (p=0.000).
- Leukopenia (p=0.043) and accelerated ESR (p=0.023) were less frequent in vaccinated individuals.
Conclusions:
- Measles vaccination significantly mitigates disease severity and duration.
- Enhanced public awareness campaigns on the importance of complete vaccination are recommended.
- Increased public procurement of vaccines is essential to ensure accessibility.
Objective:
The aim: To study the clinical and laboratory characteristics of measles, as well as to compare the course of this disease in vaccinated and unvaccinated children in the Poltava region (Ukraine).
Patients And Methods:
Materials and methods: 104 inpatients with measles were examined: vaccinated (n=27) and unvaccinated (n=77). The patient examination program included: assessment of complaints and anamnestic data obtained by questioning (during admission to hospital treatment, during treatment and after discharge) and detailed analysis of medical records (Form № 003/γ), physical examination, general clinical study of peripheral blood. Statistical processing of the study results was carried out by methods of variation statistics using the program «SPSS 17.0».
Results:
Results: The clinical and laboratory picture of measles in the examined patients is typical for this disease. Measles vaccinated children are significantly less likely to have fever (р=0.001) and Koplik's spots (χ2=3.80, р=0.051), the duration of fever (р=0.001), cough (р=0.000), and the length of hospital stay (р=0.000), as well as 3.0 times less often leukopenia is detected (р=0.043) and 2.0 times less often - acceleration of ESR (р=0.023).
Conclusion:
Conclusions: The obtained data raise the question of expanding the explanatory work on the importance of a full course of preventive vaccination among children, as well as increasing the volume of public procurement of necessary drugs to increase public access to free vaccination.
More Related Videos
08:44Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
06:22Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children
Published on: February 10, 2023
