Related Experiment Video
Updated: Oct 5, 2025
06:09
Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
7.1K
Relationship between lung function and exhaled volatile organic compounds in healthy infants
Rosa A Sola-Martínez1,2, Manuel Sanchez-Solis3,4,5, Gema Lozano-Terol1,2
1Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain.
Pediatric Pulmonology
|January 29, 2022
Summary
This study found that specific volatile organic compounds (VOCs) in infant breath are linked to lung function. Acetone, tetradecane, and pentadecane levels correlate with reduced lung capacity, potentially aiding early respiratory disease detection.
Area of Science:
- Pediatric Pulmonology
- Biochemistry
- Analytical Chemistry
Background:
- Lung function tests are vital for diagnosing chronic respiratory diseases in infants.
- Volatile organic compounds (VOCs) in exhaled breath offer a non-invasive method to monitor oxidative stress and airway inflammation.
Purpose of the Study:
- To investigate the relationship between the volatilome (VOCs in exhaled breath) and lung function in healthy infants.
- To explore the potential of VOC analysis for early detection of respiratory conditions in infants.
Main Methods:
- Lung function parameters (FVC, FEV0.5, FEF75, FEF25-75) were measured in 50 healthy infants (3-8 months) using the raised volume rapid thoracoabdominal compression technique.
- Exhaled breath was analyzed for six endogenous VOCs (acetone, isoprene, decane, undecane, tetradecane, pentadecane) using thermal desorption-gas chromatography-mass spectrometry.
Main Results:
- A significant negative association was found between acetone levels and both FVC and FEV0.5.
- Tetradecane and pentadecane levels were significantly negatively correlated with FEV0.5 and FEF25-75.
Conclusions:
- The study demonstrates a significant link between VOCs associated with oxidative stress and lung function in healthy infants.
- These findings suggest that exhaled VOC profiling could be a valuable tool for early identification of respiratory issues in infants.
Keywords:
early respiratory diseases detectionexhaled breath analysisinfant lung functionmonitorization of oxidative stressvolatile organic compoundsMore Related Videos
09:19Capturing Actively Produced Microbial Volatile Organic Compounds from Human-Associated Samples with Vacuum-Assisted Sorbent Extraction
Published on: June 1, 2022
4.2K
05:56Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
Published on: August 9, 2024
1.9K
Related Concept Videos
01:15Respiratory Volumes
2.3K
Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
2.3K
01:19Factors Affecting Pulmonary Ventilation
1.8K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.8K
01:25Pulmonary Function Tests
452
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
452
01:24Respiratory Capacities
908
Respiratory capacities are crucial indicators of lung function, representing the maximum amount of air an individual's respiratory system can handle during various breathing phases.
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
908
01:22Respiratory Volumes and Capacities
3.1K
The respiratory system is responsible for the intake of oxygen and the expulsion of carbon dioxide from the body. Respiratory volumes describe the volume of air in the lungs at different phases of the respiratory cycle. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the air that can be forcefully inspired beyond the tidal volume. In contrast, expiratory reserve volume refers to the air that can be expelled from the lungs after a normal...
3.1K
01:26Respiratory Volumes and Capacities I
1.3K
Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
1.3K