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Updated: Oct 5, 2025
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Thrombotic microangiopathy presenting with stroke-like symptoms
Farrah Nasrollahi1, Wesley Eilbert1
1Department of Emergency Medicine, University of Illinois at Chicago, College of Medicine, Room 469 COME, 1819 West Polk Street, Chicago, IL 60612, United States.
The American Journal of Emergency Medicine
|January 31, 2022
Summary
Vitamin B12 deficiency can cause thrombotic microangiopathy, a rare condition. This case highlights unusual stroke-like symptoms in an adult due to this deficiency, emphasizing the need for broader diagnostic considerations.
Area of Science:
- Hematology
- Neurology
- Internal Medicine
Background:
- Thrombotic microangiopathies (TMAs) are serious conditions involving anemia, low platelets, and organ damage.
- Common causes include Shiga toxin-producing E. coli (STEC-HUS) and atypical hemolytic uremic syndrome (aHUS).
Observation:
- A unique case of TMA in an adult patient is presented.
- The patient exhibited neurological symptoms mimicking a stroke.
Findings:
- The thrombotic microangiopathy was uniquely caused by severe vitamin B12 deficiency.
- Diagnosis required comprehensive metabolic and hematologic evaluation.
Implications:
- Vitamin B12 deficiency should be considered in the differential diagnosis of TMA, especially with neurological presentations.
- This finding expands the known spectrum of TMA etiologies and their clinical manifestations.
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