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Updated: Oct 5, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Disc Oedema in A Patient with Chronic Kidney Disease: A Diagnostic Conundrum
Jagadeesh Sutraye1, Mohan Kannam1, Srinivasa Perraju Ponnapalli2
1Academy of Eye Care Education, Child Sight Institute, Nimmagadda Prasad Children's Eye Care Centre, L V Prasad Eye Institute, Visakhapatnam, India.
Insights
This case study shows how thrombosis in the right internal jugular vein (IJV) can cause increased intracranial pressure and papilledema. Treatment with anticoagulants and carbonic anhydrase inhibitors resolved the patient's symptoms.
Area of Science:
- Neurology
- Nephrology
- Vascular Medicine
Background:
- Idiopathic intracranial hypertension and cerebral sinus venous thrombosis are common causes of papilledema.
- Internal jugular vein (IJV) thrombosis is a rare cause of increased intracranial pressure.
- Chronic kidney disease patients undergoing dialysis are at risk for venous thrombosis.
Observation:
- A 47-year-old woman with chronic kidney disease presented with headache and blurred vision.
- Bilateral papilledema was noted on examination.
- Magnetic resonance venography revealed right IJV thrombosis and signs of raised intracranial pressure.
Findings:
- The patient's symptoms and papilledema resolved with carbonic anhydrase inhibitors and anticoagulants.
- This case highlights an uncommon presentation of papilledema secondary to IJV thrombosis.
- Hypoplastic left transverse sinus may have contributed to the intracranial pressure.
Implications:
- Internal jugular vein thrombosis should be considered in the differential diagnosis of papilledema, especially in patients with risk factors.
- Early diagnosis and treatment of IJV thrombosis can prevent vision loss and other neurological complications.
- Further research is needed to understand the pathogenesis of papilledema in IJV thrombosis.
Abstract:
A 47-year-old woman who presented with headache and blurring of vision was referred to us due to suspicion of idiopathic intracranial hypertension or cerebral sinus venous thrombosis. She had chronic kidney disease and underwent dialysis through multiple ports including the right internal jugular vein (IJV). Her examination showed a best corrected visual acuity of 20/20 in each eye, normal anterior segments in each eye but bilateral papilloedema. Magnetic resonance imaging and venography (MRV) of her brain with contrast showed signs of raised intracranial pressure and a hypoplastic left transverse sinus. An MRV of her neck showed a thrombosis of the right IJV. Her symptoms and papilloedema resolved with carbonic anhydrase inhibitors and anticoagulants. This case highlights an uncommon presentation of papilloedema secondary to raised intracranial pressure from IJV thrombosis and its pathogenesis.
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