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Inner Retinal Layer Disease: Multiple Sclerosis
Mehmet Cem Sabaner1, Resat Duman2, Rahmi Duman3
1Department of Ophthalmology, Bafra State Hospital, Samsun, Turkey.
Beyoglu Eye Journal
|January 31, 2022
Summary
Multiple sclerosis (MS) thins inner retinal layers, including the ganglion cell layer (GCL) and inner plexiform layer (IPL), as shown by spectral-domain optical coherence tomography (SD-OCT) retinal imaging.
Area of Science:
- Ophthalmology
- Neurology
- Medical Imaging
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Retinal layer thickness changes can indicate neurological conditions.
Purpose of the Study:
- To analyze retinal layer thickness in MS patients using spectral-domain optical coherence tomography (SD-OCT).
- To compare retinal layer thickness between MS patients with and without a history of optic neuritis and healthy controls.
Main Methods:
- 42 MS patients and 21 healthy controls were included.
- Patients were categorized into four groups based on MS diagnosis and optic neuritis history.
- Spectral-domain optical coherence tomography (SD-OCT) was used to measure retinal layer thickness.
Main Results:
- MS patients showed thinner ganglion cell layer (GCL) and inner plexiform layer (IPL) compared to controls.
- Patients with a history of optic neuritis had thinner retinal nerve fiber layer (RNFL) in all regions.
- While Group 3 (MS without optic neuritis) showed thinner layers than Group 1 (MS without eye involvement), differences were not significant.
Conclusions:
- Multiple sclerosis (MS) significantly affects retinal layer thickness, particularly the inner retinal layers.
- SD-OCT is a valuable tool for detecting microstructural changes in the retina associated with MS.
