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Function of miRNA-145-5p in the pathogenesis of human disorders

Sepideh Kadkhoda1, Soudeh Ghafouri-Fard2

  • 1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Pathology, Research and Practice
|February 1, 2022
PubMed

Insights

MicroRNA-145-5p (miR-145-5p) acts as a tumor suppressor in many cancers but can be upregulated in others. This microRNA also impacts non-malignant conditions like asthma and arthritis.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNA-145-5p (miR-145-5p), encoded by the MIR145 gene on chromosome 5, is implicated in various diseases.
  • It is primarily recognized as a tumor suppressor in multiple cancers, including bladder, breast, cervical, cholangiocarcinoma, renal, and gastrointestinal cancers.

Purpose of the Study:

  • To review the current literature on the multifaceted roles of miR-145-5p.
  • To consolidate understanding of its involvement in both malignant and non-malignant conditions.

Main Methods:

  • Literature review of studies investigating miR-145-5p.
  • Analysis of its expression patterns and functional roles in disease pathogenesis.

Main Results:

  • miR-145-5p generally functions as a tumor suppressor, but its upregulation has been observed in certain cancers.
  • Evidence suggests miR-145-5p influences the pathogenesis of non-malignant conditions such as aplastic anemia, asthma, cerebral ischemia/reperfusion injury, diabetic nephropathy, rheumatoid arthritis, and Sjögren syndrome.

Conclusions:

  • miR-145-5p exhibits complex roles in disease, acting as a tumor suppressor in many cancers while also affecting non-malignant disorders.
  • Further research is warranted to fully elucidate the therapeutic potential of targeting miR-145-5p.
Keywords:
BiomarkerCancerMiR-145–5p

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