Related Experiment Video
Updated: Oct 5, 2025

Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
Published on: April 15, 2017
Direct Compaction Drug Product Process Modeling
Alexander Russell1, John Strong2, Sean Garner2
1Operations Science & Technology, AbbVie, 67061, Ludwigshafen, Germany. alexander.russell@abbvie.com.
Abstract:
Most challenges during the development of solid dosage forms are related to the impact of any variations in raw material properties, batch size, or equipment scales on the product quality and the control of the manufacturing process. With the ever pertinent restrictions on time and resource availability versus heightened expectations to develop, optimize, and troubleshoot manufacturing processes, targeted and robust science-based process modeling platforms are essential. This review focuses on the modeling of unit operations and practices involved in batch manufacturing of solid dosage forms by direct compaction. An effort is made to highlight the key advances in the past five years, and to propose potentially beneficial future study directions.
More Related Videos
15:04Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Published on: May 20, 2016
09:56Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
Published on: December 23, 2022
Related Concept Videos
In Vitro Drug Dissolution: Compendial Testing Models I
Compartment Models: Two-Compartment Model
In Vitro Drug Dissolution: Compendial Testing Models II
Model Approaches for Pharmacokinetic Data: Compartment Models
Two primary types of compartment models are recognized: mammillary and catenary. The more...
Three-Compartment Open Model
Drug Dissolution: Requirements and Profile Comparison