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Primary pleural synovial sarcoma in an adolescent: a case report
Yanyan Xu1,2, Jie Lin3, Hongliang Sun2
1Department of Radiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.
Translational Cancer Research
|February 4, 2022
Summary
Primary pleural synovial sarcoma (SS) is a rare childhood cancer. This case highlights its challenging diagnosis in adolescents, emphasizing consideration of SS in intrathoracic masses with recurrent pleural effusion.
Area of Science:
- Oncology
- Pediatric Oncology
- Thoracic Surgery
Background:
- Primary pleural synovial sarcoma (SS) is exceptionally rare in pediatric and adolescent populations.
- The diagnosis of SS in this location presents a significant clinical challenge due to its rarity and variable histogenesis.
Observation:
- A 14-year-old male presented with chest pain and dyspnea, progressing to recurrent hemorrhagic pleural effusion.
- Imaging revealed a large, enhancing solid mass in the right hemithorax with massive pleural effusion, notably without lymphadenopathy.
- Routine hematological tests were largely normal, with a noted decrease in eosinophils.
Findings:
- Surgical resection and subsequent morphological and immunohistochemical analysis confirmed a biphasic synovial sarcoma.
- The patient recovered well post-surgery with no immediate complications and was scheduled for adjuvant chemotherapy.
Implications:
- Pleural SS, though rare, must be included in the differential diagnosis for intrathoracic masses in adolescents, particularly those presenting with recurrent hemorrhagic pleural effusion.
- Early consideration and accurate diagnosis are crucial for timely and effective management of this rare pediatric malignancy.
