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Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules
Published on: September 16, 2022
[Alpha-gal syndrome : Overview of clinical presentation and pathophysiology]
J Fischer1,2, T Reepschläger3, T Schricker3
1Universitätsklinik für Dermatologie und Allergologie, Klinikum Oldenburg AöR und Abteilung für experimentelle Allergologie und Immundermatologie, Carl von Ossietzky Universität Oldenburg, Rahel-Straus-Str. 10, 26133, Oldenburg, Deutschland. fischer.joerg@klinikum-oldenburg.de.
Abstract:
In the world of allergology, alpha-gal syndrome remains one of the most fascinating discoveries over the last 15 years as it is triggered by specific IgE directed against the immunogenic sugar galactose-α‑1,3‑galactose (alpha-gal), found foremost in mammalian meat, milk and products derived thereof, potentially resulting in anaphylaxis. Also, mammalian-derived drugs and medical products have been identified as possible culprits. Nonetheless, tick bites remain the major cause of specific alpha-gal-sIgE. Herein, we summarize the current clinical knowledge and pathophysiology of alpha-gal syndrome in order to better understand this disease.
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