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Related Experiment Video

Updated: Oct 4, 2025

Methods for Detecting Cough and Airway Inflammation in Mice
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Published on: August 2, 2024

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Effect of prolonged mechanical ventilation on cough function and TRPV1 expression.

Tissot Low1, Chien-Hui Lee2, Yen-Cheng Chen3

  • 1Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan; Division of Chest Medicine, Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Respiratory Physiology & Neurobiology
|February 5, 2022
PubMed
Summary

Prolonged mechanical ventilation impairs cough reflex sensitivity and strength. This dysfunction necessitates targeted airway clearance management and rehabilitation for affected patients.

Keywords:
CapsaicinCough reflex sensitivityCough strengthExtubationProlonged mechanical ventilationTRPV1

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Area of Science:

  • Pulmonology
  • Critical Care Medicine
  • Respiratory Physiology

Background:

  • Cough is a vital airway protective reflex.
  • The impact of prolonged mechanical ventilation (PMV) on cough function remains largely uncharacterized.
  • Understanding these effects is crucial for patient recovery and preventing complications.

Purpose of the Study:

  • To compare cough function between patients undergoing prolonged mechanical ventilation (PMV) and short-term mechanical ventilation (SMV).
  • To investigate the underlying mechanisms, including cough reflex sensitivity, respiratory muscle strength, and TRPV1 expression.

Main Methods:

  • Assessed cough reflex sensitivity using capsaicin provocation concentrations post-extubation.
  • Measured cough strength via involuntary cough peak expiratory flow (iCPEF).
  • Quantified mRNA expression of transient receptor potential vanilloid 1 (TRPV1) in tracheal tissues.

Main Results:

  • Patients with PMV exhibited significantly reduced cough reflex sensitivity compared to the SMV group.
  • Involuntary cough peak expiratory flow (iCPEF) was notably lower in the PMV cohort.
  • Tracheal TRPV1 mRNA expression levels were comparable between the PMV and SMV groups.

Conclusions:

  • Prolonged mechanical ventilation leads to significant cough dysfunction, affecting both reflex sensitivity and expiratory strength.
  • The observed cough impairment does not appear to be directly linked to alterations in tracheal TRPV1 expression.
  • Clinical recommendations include implementing robust airway clearance strategies and rehabilitation programs for patients recovering from prolonged mechanical ventilation.