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Local Field Potential-Based Programming: A Proof-of-Concept Pilot Study.

Alfonso Fasano¹, Carolina Gorodetsky², Darcia Paul³

¹Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, ON, Canada; Division of Neurology, University of Toronto, Toronto, ON, Canada; Krembil Brain Institute, University Health Network, Toronto, ON, Canada; Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada; KITE, University Health Network, Toronto, ON, Canada.

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|February 7, 2022

Summary

This summary is machine-generated.

Local field potential (LFP)-based programming streamlines deep brain stimulation (DBS) for conditions with delayed benefits. This pilot study shows LFP monitoring effectively guides DBS adjustments in dystonia and epilepsy patients.

Keywords:

Deep brain stimulation local field potential neuromodulation percept programming

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Area of Science:

Neuroscience
Biomedical Engineering

Background:

Deep brain stimulation (DBS) programming is often trial-and-error, especially for conditions with delayed clinical response.
Current programming strategies are limited and primarily focus on Parkinson's disease.

Purpose of the Study:

To demonstrate the efficacy of local field potential (LFP)-based programming for DBS.
To streamline DBS programming for indications with delayed temporal onset of benefit.

Main Methods:

Utilized a commercial implantable pulse generator (IPG) capable of chronic LFP streaming and recording.
Programmed DBS in a pediatric patient with generalized dystonia and an adult with refractory epilepsy.

Main Results:

Identified specific LFP frequency peaks (e.g., 1.95 Hz delta range) correlated with symptom severity in dystonia.
Observed reduced LFP power at specific frequencies (2.93 Hz, 8.79 Hz) associated with seizure control in epilepsy.

Conclusions:

LFP-based programming offers a promising approach to optimize DBS settings.
This method can potentially reduce programming time and improve outcomes for complex DBS indications.