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Updated: Oct 4, 2025

A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo
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Molecular Tools for Targeted Control of Nerve Cell Electrical Activity. Part II.

D V Kolesov1, E L Sokolinskaya1, K A Lukyanov1

  • 1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997 Russia.

Acta Naturae
|February 7, 2022
PubMed
Summary
This summary is machine-generated.

Chemogenetics and thermogenetics offer precise control over cell activity by introducing external stimulus-sensitive molecules into nervous tissue. These minimally invasive techniques complement optogenetics for studying complex neural systems.

Keywords:
GPCRaction potentialchannelrhodopsinchemogeneticschemoreceptorsion channelsmembrane voltageneural activity stimulationneural excitationneural inhibitionneurointerfaceoptogeneticsthermogenetics

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Area of Science:

  • Life Sciences
  • Neuroscience
  • Biochemistry

Background:

  • Controlling cellular biochemistry, particularly the electrical activity of excitable cells, is a key challenge in modern life sciences.
  • Understanding the nervous system's function necessitates minimally invasive brain tissue stimulation methods.

Purpose of the Study:

  • To review exogenous, genetically encoded molecule-based approaches for controlling neural activity.
  • To describe chemogenetics and thermogenetics as complementary techniques to optogenetics.

Main Methods:

  • Delivery of exogenous, genetically encoded molecules sensitive to external stimuli into nervous tissue.
  • Utilizing chemogenetics and thermogenetics for targeted neural manipulation.

Main Results:

  • Chemogenetics and thermogenetics provide methods to control cellular electrical activity (excitation or inhibition).
  • These techniques differ from optogenetics in stimuli nature and effector proteins, indicating complementary roles.

Conclusions:

  • Chemogenetics and thermogenetics are valuable, minimally invasive tools for neuroscience research.
  • These methods offer distinct advantages and applications, complementing optogenetics in studying complex neuronal systems.