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Related Experiment Video

Updated: Oct 4, 2025

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
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Cost-related nonadherence can be explained by a general nonadherence framework.

Qais Alefan, Vishnu Meghana Cheekireddy, David Blackburn

    Journal of the American Pharmacists Association : Japha
    |February 8, 2022
    PubMed
    Summary
    This summary is machine-generated.

    Cost-related nonadherence (CRNA) to medications is common. However, this review found that existing frameworks for general medication nonadherence adequately explain CRNA, challenging the need for a distinct model.

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    Area of Science:

    • Health Services Research
    • Pharmacoeconomics
    • Patient Adherence

    Background:

    • A specific conceptual framework for cost-related nonadherence (CRNA) has been proposed, distinct from general medication nonadherence models.
    • Understanding the unique drivers of CRNA is crucial for developing targeted interventions.

    Purpose of the Study:

    • To evaluate whether studies on CRNA are best explained by a conceptual framework developed for general medication nonadherence.
    • To determine if CRNA requires a distinct theoretical model separate from general nonadherence.

    Main Methods:

    • A systematic literature review was conducted across major databases (MEDLINE, CINAHL, ScienceDirect, Google Scholar) from 2008 to 2020.
    • Included studies focused on CRNA, utilized self-reported measures, and reported associated factors.
    • 58 relevant research studies were identified and analyzed.

    Main Results:

    • Financial pressures consistently correlated with CRNA, aligning with both CRNA-specific and general nonadherence frameworks.
    • Non-economic factors (patient, disease, clinician) showed independent effects, similar in strength to economic factors.
    • Risk factor patterns in CRNA largely mirrored general nonadherence, with poor health being an exception, likely due to population differences.

    Conclusions:

    • Financial difficulties are prevalent among medication users, contributing significantly to nonadherence.
    • Current evidence does not support a distinct conceptual framework for CRNA, suggesting general nonadherence models are applicable.
    • Further research may clarify the nuanced relationship between health status and CRNA.