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Updated: Oct 4, 2025

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Published on: July 6, 2019

Lipoid Pneumonia.

Hau C Chieng¹, Ammoura Ibrahim², Woon H Chong¹

¹Division of Pulmonary & Critical Care Medicine, Department of Medicine, Albany Medical College, Albany, NY, United States.

The American Journal of the Medical Sciences

|February 8, 2022

Summary

This summary is machine-generated.

Exogenous lipoid pneumonia, caused by lipid aspiration, can mimic lung cancer. Early recognition is key, especially in patients with risk factors for aspiration and suspicious lung nodules.

Keywords:

Groundglass opacity Lung nodules

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Area of Science:

Pulmonology
Radiology
Pathology

Background:

Lipoid pneumonia is characterized by lipid accumulation in lung tissue, with varying incidence in adults and children.
It originates from exogenous (lipid aspiration) or endogenous (alveolar cell destruction) sources.
Exogenous lipoid pneumonia is frequently linked to the aspiration of fatty substances.

Observation:

A 75-year-old male presented with incidentally discovered spiculated lung nodules on abdominal CT.
Symptoms included weight loss and a history of constipation.
PET/CT imaging showed spiculated nodules with positive fluorodeoxyglucose (FDG) uptake.

Findings:

Histopathology following wedge resection confirmed exogenous lipoid pneumonia with a granulomatous reaction.
The case highlights clinical, radiological, and pathological features of this condition.
The presentation mimicked invasive adenocarcinoma.

Implications:

A high index of suspicion for exogenous lipoid pneumonia is crucial.
Consider this diagnosis in patients with abnormal chest imaging and aspiration risk factors.
Differentiating it from lung cancer is essential for appropriate patient management.