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Updated: Oct 4, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
Published on: July 25, 2019
Non-proteolytic ubiquitylation in cellular signaling and human disease
Yongrong Liao1,2,3,4, Izabela Sumara5,6,7,8, Evanthia Pangou9,10,11,12
1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Abstract:
Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation. However it can also result in non-proteolytic events which play important functions in cellular processes such as intracellular signaling, membrane trafficking, DNA repair and cell cycle. Emerging evidence demonstrates that dysfunction of non-proteolytic ubiquitylation is associated with the development of multiple human diseases. In this review, we summarize the current knowledge and the latest concepts on how non-proteolytic ubiquitylation pathways are involved in cellular signaling and in disease-mediating processes. Our review, may advance our understanding of the non-degradative ubiquitylation process.
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