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Updated: Jun 17, 2025
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Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
Published on: May 16, 2017
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Cytoplasmic nucleoporin assemblage: the cellular artwork in physiology and disease
Junyan Lin1,2,3,4, Izabela Sumara1,2,3,4
1Department of Development and Stem Cells, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch, France.
Nucleus (Austin, Tex.)
|August 13, 2024
Summary
Cytoplasmic nucleoporins, typically nuclear pore proteins, have unexpected roles beyond transport. This review explores their structures, dynamics, and functions in various cellular states, revealing new physiological and pathological implications.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Nucleoporins (Nups) form the nuclear pore complex (NPC), regulating nucleocytoplasmic transport.
- Traditionally, Nups are confined to the nuclear envelope.
- Emerging evidence suggests Nups exist in cytoplasmic assemblies with non-transport functions.
Purpose of the Study:
- To review and consolidate current knowledge on cytoplasmic nucleoporin assemblies.
- To explore the structural organization, formation dynamics, and functional implications of these assemblies.
- To enhance understanding of Nup homeostasis and their roles in physiological and pathological processes.
Main Methods:
- Literature review of existing studies on nucleoporins.
- Analysis of findings across normal physiological conditions, cellular stress, and pathological states.
- Synthesis of current concepts on nucleoporin regulation and function.
Main Results:
- Cytoplasmic nucleoporin assemblies are observed in various cellular conditions.
- These assemblies exhibit distinct structural organizations and formation dynamics.
- Nups in the cytoplasm may have significant roles beyond canonical nucleocytoplasmic transport.
Conclusions:
- Nucleoporins possess diverse, non-canonical functions in the cytoplasm.
- Understanding cytoplasmic Nup assemblies is crucial for comprehending cellular homeostasis and disease.
- Further research into Nup regulation and function in cytoplasmic structures is warranted.
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