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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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Novel antifungal agents in clinical trials

Samantha E Jacobs1, Panagiotis Zagaliotis2, Thomas J Walsh2,3

  • 1Division of Infectious Diseases, Icahn School of Medicine, New York, NY, 10029-5674, USA.

F1000Research
|February 10, 2022
PubMed

Insights

Novel antifungal drugs are urgently needed to combat rising invasive fungal diseases. This review covers promising investigational agents, including new classes and improved existing treatments, to address this public health threat.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Invasive fungal diseases (IFDs) pose a significant and growing public health risk.
  • Increasing immunosuppressed populations and antifungal resistance exacerbate the threat of IFDs.
  • High morbidity and mortality associated with IFDs necessitate the development of new therapies.

Purpose of the Study:

  • To review promising investigational antifungal agents currently in clinical development.
  • To highlight novel antifungal classes and agents with improved pharmacokinetic/pharmacodynamic properties.
  • To address the urgent need for safe and effective treatments against resistant fungal pathogens.

Main Methods:

  • Literature review of antifungal agents in clinical development phases.
  • Focus on novel first-in-class antifungals and improved existing agents.
  • Discussion of agents targeting resistant yeasts and molds.

Main Results:

  • Identified several promising investigational antifungal agents: fosmanogepix, ibrexafungerp, rezafungin, encochleated amphotericin B, oteseconazole (VT-1161), VT-1598, PC945, and olorofim.
  • Highlighted three first-in-class agents from novel antifungal classes.
  • Noted new agents within existing classes with enhanced safety and tolerability.

Conclusions:

  • Investigational antifungal agents show promise in addressing the challenge of resistant IFDs.
  • Development of novel therapeutics is crucial for managing the increasing burden of IFDs.
  • Improved drug profiles offer potential for better patient outcomes in treating fungal infections.
Keywords:
Antifungal Agentsclinical trialsnovel treatmentspharmacokinetic and pharmacodynamic

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