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Updated: Oct 4, 2025

Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species
Published on: May 7, 2018
Discrimination and quantitation of halobenzoic acid positional isomers upon Th(IV) coordination by mass spectrometry
Xiuting Chen1, Zhixin Xiong1,2, Meixian Yang1,2
1Department of Radiochemistry, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China. gongyu@sinap.ac.cn.
Abstract:
A fast and reliable mass spectrometry-based method has been developed to discriminate the positional isomers of o-, m- and p-C6H4XCO2H (X = F, Cl and Br). This is based on the distinct fragmentation patterns of isomeric ThCl4(C6H4XCO2)- ions generated by electrospray ionization of the solutions with C6H4XCO2H isomers and ThCl4. Moreover, the composition of these positional isomers can be conveniently quantified without any pre-treatment according to the proportion of gas-phase fragmentation products.
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