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Expanding the Toolkit for In Vivo Imaging of Axonal Transport
Published on: December 23, 2021
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Neuronal endolysosomal transport and lysosomal functionality in maintaining axonostasis
Joseph C Roney1, Xiu-Tang Cheng1, Zu-Hang Sheng1
1Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
The Journal of Cell Biology
|February 10, 2022
Summary
Lysosomes are crucial for neuron health, clearing waste via transport along axons. Disruptions in this process contribute to neurodegenerative diseases and aging.
Area of Science:
- Neuroscience
- Cell Biology
- Molecular Biology
Background:
- Lysosomes are vital for cellular waste degradation, essential for neuron function and survival.
- Impaired lysosome function is linked to neurodegenerative diseases and aging.
- Neurons' unique structure presents challenges for maintaining lysosome function in distant axonal regions.
Purpose of the Study:
- To review recent advances in understanding axonal endolysosomal trafficking and lysosomal function in neuronal health.
- To explore how disruptions in these processes contribute to neurodegenerative diseases.
Main Methods:
- This review synthesizes findings from recent research on endolysosomal trafficking in neurons.
- It examines molecular mechanisms and signaling pathways regulating transport and maturation.
Main Results:
- Bidirectional intracellular transport is critical for maintaining lysosome function in distal axons.
- Specific mechanisms governing endolysosome transport and maturation are being uncovered.
- Dysregulation of axonal endolysosomal trafficking is implicated in neurodegeneration.
Conclusions:
- Efficient axonal endolysosomal trafficking and lysosomal functionality are crucial for neuronal homeostasis (axonostasis).
- Understanding these processes offers insights into neurodegenerative disease pathogenesis.
- Further research into these mechanisms may reveal therapeutic targets.
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