Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 4, 2025

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

941

Multi-regional module-based signal transmission in mouse visual cortex.

Xiaoxuan Jia1, Joshua H Siegle1, Séverine Durand1

  • 1Allen Institute, Seattle, WA 98109, USA.

Neuron
|February 10, 2022
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional Insights into the RCC1 Gene Family and UVR8-Mediated Regulation of Anthocyanin Biosynthesis in Grapevine.

Plants (Basel, Switzerland)·2026
Same author

Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.

Nature methods·2026
Same author

Systematic profiling of aroma and quality in UV-B treated grapes across fruit development stages.

Food research international (Ottawa, Ont.)·2026
Same author

Mapping neuronal selectivity and invariance in the mammalian visual cortex using digital twins.

Trends in neurosciences·2026
Same author

Large-scale electrophysiology at single-spike resolution.

Nature reviews. Neuroscience·2026
Same author

Topographic structure and function of locus coeruleus norepinephrine neurons.

bioRxiv : the preprint server for biology·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
Same journal

Microglial fitness in moderation: Tuning TREM2 signaling through Ptpn6.

Neuron·2026
Same journal

Human astrocytes keep time with inflammation.

Neuron·2026
See all related articles

Researchers mapped neuronal communication across the mouse visual cortex, revealing two distinct functional modules. One module handles feedforward sensory signals, while the other integrates inputs for recurrent processing in hierarchical networks.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • The visual cortex exhibits hierarchical organization with complex recurrent and parallel pathways.
  • Understanding signal flow between neuronal populations in this network is challenging.

Purpose of the Study:

  • To investigate the directed flow of spiking activity across multiple interconnected levels of the mouse visual hierarchy.
  • To identify functional communication modules within the visual cortex.

Main Methods:

  • Recorded simultaneous spiking activity from neurons across six levels of the mouse visual hierarchy.
  • Analyzed spike-timing relationships to construct a cellular-scale directed network graph.
  • Applied a module-detection algorithm to cluster neurons based on connectivity patterns.
Keywords:
Neuropixelsfeedforwardfunctional networkmodularmouseprocessing stagesrecurrentvisual cortex

More Related Videos

Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice
08:26

Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice

Published on: August 23, 2022

2.5K
Visualization of Cortical Modules in Flattened Mammalian Cortices
08:49

Visualization of Cortical Modules in Flattened Mammalian Cortices

Published on: January 22, 2018

13.1K

Related Experiment Videos

Last Updated: Oct 4, 2025

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

941
Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice
08:26

Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice

Published on: August 23, 2022

2.5K
Visualization of Cortical Modules in Flattened Mammalian Cortices
08:49

Visualization of Cortical Modules in Flattened Mammalian Cortices

Published on: January 22, 2018

13.1K

Main Results:

  • Uncovered two distinct multi-regional communication modules distributed across the visual hierarchy.
  • Identified differences in signal flow direction, layer/area distribution, and temporal dynamics between modules.
  • One module showed characteristics of feedforward sensory signal transmission, while the other supported recurrent processing.

Conclusions:

  • Multi-regional functional modules are a fundamental organizational principle in the visual cortex.
  • These modules facilitate signal propagation across hierarchical and recurrent neural networks.
  • The identified modules likely support distinct computational roles, such as sensory processing and integration.