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Updated: Oct 4, 2025

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
[Long-term follow-up of persons living with HIV]
1Unité d'immunoinfectiologie, centre de diagnostic et de thérapeutique, Hôtel-Dieu, Paris, France.
Insights
People with HIV are living longer, facing age-related health issues. Regular screenings for conditions like cardiovascular disease and osteoporosis are crucial for managing long-term HIV care.
Area of Science:
- Geriatric Medicine
- Infectious Diseases
- Public Health
Background:
- Long-term HIV survival rates are increasing, approaching those of the general population.
- Individuals with HIV face unique age-related comorbidities and complications.
- Both traditional and HIV/treatment-specific risk factors contribute to health challenges.
Purpose of the Study:
- To highlight the evolving healthcare needs of aging individuals with HIV.
- To emphasize the necessity of proactive screening and preventive measures.
- To advocate for a comprehensive, multidisciplinary approach to managing long-term HIV care.
Main Methods:
- Review of current literature on long-term HIV management.
- Analysis of age-related comorbidities in HIV-positive cohorts.
- Assessment of risks associated with prolonged antiretroviral therapy.
Main Results:
- HIV-positive individuals are increasingly susceptible to age-related diseases.
- Screening for cardiovascular disease, hyperglycemia, dyslipidemia, osteoporosis, and malignancies is recommended.
- Antiretroviral drugs, while improved, still pose long-term considerations.
Conclusions:
- Aging populations with HIV require tailored screening protocols.
- Preventive strategies are essential to mitigate comorbidities.
- A global, multidisciplinary approach is vital for optimal long-term HIV care.
Abstract:
Long-term Follow-up of persons Living with hiv Life expectancy of persons living with Hiv is reaching that of the general population. In consequence they are exposed To age-related comorbidities and Complications, with both classical and Hiv- or treatment-related risk factors. Patients with long treatment histories Should therefore be screened for cardiovascular Disease, hyperglycemia and Dyslipidemia, osteoporosis and certain Malignancies. Preventive actions should Be implemented. Although current antiretroviral Drugs are considerably less Toxic than first generation medications, Patient cohorts will inexorably become Older and accumulate comorbidities and Comedications. This evolution warrants a Global and mutidisciplinary approach to Medical care.
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