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Tuberculosis in Children

Devan Jaganath1, Jeanette Beaudry2, Nicole Salazar-Austin3

  • 1Division of Pediatric Infectious Diseases, University of California, San Francisco, 1001 Potrero Avenue, Building 3, Room 635A, Box 1234, San Francisco, CA 94110, USA.

Infectious Disease Clinics of North America
|February 16, 2022
PubMed

Insights

Diagnosing and treating childhood tuberculosis (TB) is crucial to prevent disease progression and transmission. This review covers current clinical approaches and emerging strategies for pediatric TB infection and disease.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Tuberculosis (TB) remains a major global cause of child mortality.
  • Effective diagnosis and treatment of pediatric TB face significant challenges.
  • Preventing TB progression and transmission in children is vital for public health.

Purpose of the Study:

  • To review the clinical approach for diagnosing and treating latent TB infection and TB disease in children.
  • To discuss emerging diagnostics and therapeutics for pediatric TB.
  • To improve outcomes for children affected by TB.

Main Methods:

  • Literature review of clinical guidelines and research on pediatric TB.
  • Analysis of current diagnostic strategies for latent and active TB in children.
  • Evaluation of established and novel therapeutic regimens for pediatric TB.

Main Results:

  • Current diagnostic and treatment protocols for pediatric TB are detailed.
  • Emerging technologies offer potential improvements in TB detection.
  • New therapeutic options aim to enhance treatment efficacy and reduce duration.

Conclusions:

  • Optimizing diagnosis and treatment of pediatric TB is essential to reduce mortality and transmission.
  • Advancements in diagnostics and therapeutics are critical for improving pediatric TB outcomes.
  • A comprehensive approach is needed to address the global burden of childhood TB.

Keywords:
ChildDiagnosisPreventionTBTreatmentTuberculosis

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