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Updated: Oct 3, 2025

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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
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Self-catalyzed tumor ferroptosis based on ferrocene conjugated reactive oxygen species generation and a responsive
Jisi Li1, Qingyu Zong1, Ye Liu1,2
1School of Medicine, South China University of Technology, Guangzhou, 510006, P. R. China. yuanyy@scut.edu.cn.
Abstract:
In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed ˙OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectively induced tumor ferroptosis, which provided a novel approach for enhanced tumor therapy.

