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Oxygen flux into the aberrant cornea
American Journal of Optometry and Physiological Optics
|April 1, 1986
Summary
Post-surgical human corneas show reduced oxygen uptake. This difference is more detectable at high oxygen levels, explaining previous null findings with specific methods.
Area of Science:
- Ophthalmology
- Corneal Physiology
- Biomedical Engineering
Background:
- Polarographic oxygen sensors suggest reduced post-surgical corneal epithelial oxygen consumption.
- Conflicting results exist regarding post-surgical corneal oxygen uptake, particularly with the Rasson-Fatt method under thick soft contact lenses.
Purpose of the Study:
- To reconcile conflicting findings on post-surgical corneal oxygen uptake.
- To investigate the influence of precorneal oxygen tension on detecting differences in corneal oxygen consumption.
Main Methods:
- Utilized a three-layer computer model of corneal oxygen distribution.
- Analyzed oxygen flux differences at varying precorneal oxygen tensions.
Main Results:
- The difference in corneal oxygen flux between normal and post-surgical corneas is amplified at high precorneal oxygen tensions.
- The difference is minimal at low precorneal oxygen tensions, potentially masking post-surgical changes.
Conclusions:
- The Hill-Fatt method's measurement area (high oxygen tension) enhances detection of reduced post-surgical corneal oxygen uptake.
- The Rasson-Fatt method's sensitivity to low oxygen tensions may explain previously reported null results.