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Nicotinamide N-Methyltransferase in Health and Cancer
David B Ramsden1, Rosemary H Waring2, David J Barlow3
1Institute of Metabolism and Systems Research, The Medical School, University of Birmingham, Birmingham, UK.
International Journal of Tryptophan Research : IJTR
|February 21, 2022
Summary
Nicotinamide N-methyltransferase (NNMT) and its product 1-methyl nicotinamide are crucial in human health and cancer. This review details their structure and role in common cancers.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Nicotinamide N-methyltransferase (NNMT) and 1-methyl nicotinamide were once considered minor players in xenobiotic metabolism.
- Recent research highlights their significant involvement in critical human biological processes.
Purpose of the Study:
- To review the structural aspects of the NNMT gene, messenger RNA, and protein.
- To elucidate the role of NNMT in the development of common human cancers.
Main Methods:
- Literature review of existing studies on NNMT.
- Analysis of structural data for NNMT gene, mRNA, and protein.
- Examination of NNMT's involvement in cancer pathways.
Main Results:
- Detailed structural information of NNMT, its mRNA, and protein is presented.
- NNMT's significant role in various common human cancers is discussed.
Conclusions:
- NNMT and 1-methyl nicotinamide are key factors in human health and disease.
- Understanding NNMT's structure and function is vital for cancer research and potential therapeutic strategies.
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