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Microinjection of Medaka Embryos for use as a Model Genetic Organism
Published on: December 22, 2010
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The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel.
Tomas Fitzgerald1, Ian Brettell1, Adrien Leger1
1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Genome Biology
|February 22, 2022
Summary
Researchers developed the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel, a new resource of 80 inbred medaka fish lines. This panel facilitates robust genotype-to-phenotype studies for complex genetic traits.
Area of Science:
- Genetics
- Developmental Biology
- Comparative Genomics
Background:
- Mapping genetic variants to complex traits is challenging due to environmental factors.
- The teleost medaka (Oryzias latipes) is a well-established genetic model organism.
- Medaka exhibit high tolerance to inbreeding, making them suitable for genetic resource development.
Purpose of the Study:
- To establish a novel vertebrate genetic resource for genotype-to-phenotype investigations.
- To enable controlled studies varying genetics and environment.
- To facilitate phenotype-to-genotype association studies for complex traits.
Main Methods:
- Development of the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel.
- Creation of 80 near-isogenic inbred medaka lines from a wild founder population.
- Characterization of genetic variation across the MIKK panel.
Main Results:
- The MIKK panel is the first near-isogenic panel of 80 inbred lines in a vertebrate model derived from a wild founder population.
- Inbred lines provide fixed genomes crucial for reproducible research.
- The panel enables controlled manipulation of genetic and environmental factors.
Conclusions:
- The MIKK panel offers a unique genetic resource for the scientific community.
- It enables large-scale experiments for mapping complex genetic traits.
- Applications span genetic research, human health, drug development, and fundamental biology.
