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Acoustically manipulating internal structure of disk-in-sphere endoskeletal droplets
Gazendra Shakya1, Tao Yang1, Yu Gao1
1Paul M. Rady Department of Mechanical Engineering, University of Colorado, Boulder, CO, 80309, USA.
Nature Communications
|February 22, 2022
Summary
Acoustic waves enable precise control over the internal structure of disk-in-sphere droplets. This allows for reversible manipulation and novel arrangements of colloidal architectures and cellular components.
Area of Science:
- Physics
- Materials Science
- Biotechnology
Background:
- Micro/nano particle manipulation is established using optical, electromagnetic, and acoustic methods.
- Controlling the internal structure of droplets/particles is complex and less explored.
Purpose of the Study:
- To demonstrate and model the manipulation of internal structure in disk-in-sphere endoskeletal droplets using acoustic waves.
- To investigate the physical mechanisms governing these internal structural dynamics.
Main Methods:
- Utilized acoustic waves to manipulate the internal structure of disk-in-sphere droplets.
- Developed a theoretical model to analyze acoustic interactions and radiation forces.
Main Results:
- Acoustic interactions are governed by a balance of primary and secondary radiation forces.
- Disk orientation within droplets can be reversibly adjusted by altering acoustic driving frequency.
- Achieved dynamic, reversible arrangements of endoskeletal droplets and their internal architecture.
Conclusions:
- Acoustic manipulation offers a novel method for controlling droplet internal structure.
- This technique facilitates the directed assembly of hierarchical colloidal architectures.
- Potential applications include the manipulation of intracellular organelles and intra-organoid structures.
