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Updated: Oct 2, 2025
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
[Analysis of coagulation state in sudden deafness patients with total deafness and vertigo]
Wenping Guo1, Yongtao Qu2, Mingli Guo2
1Department of Otolaryngology Head and Neck Surgery，Shijiazhuang People's Hospital，Shijiazhuang，050057，China.
Insights
Sudden deafness with vertigo shows more severe hypercoagulability, indicating thrombosis may influence total deafness. This patient group has the poorest prognosis compared to other sudden deafness types.
Area of Science:
- Otolaryngology
- Hematology
- Vascular Medicine
Background:
- Sudden deafness is a complex condition with multifactorial causes.
- Coagulation abnormalities are increasingly recognized as potential contributors to inner ear vascular events.
Purpose of the Study:
- To investigate the coagulation status in patients with sudden deafness accompanied by vertigo.
- To analyze the prognosis of sudden deafness patients with total deafness and vertigo.
- To establish a basis for improved treatment strategies.
Main Methods:
- A cohort study comparing 33 patients with total deafness and vertigo to control groups (other sudden deafness types and healthy individuals).
- Analysis of coagulation parameters including fibrinogen (FIB), D-Dimer (D-D), Prothrombin Time (PT), and Activated Partial Thrombin Time (APTT).
- Evaluation of therapeutic effects and curative rates across different sudden deafness classifications.
Main Results:
- Patients with total deafness and vertigo exhibited significantly higher FIB and D-D levels compared to the normal control group (P<0.01).
- This group also showed significantly lower APTT levels than the normal control group (P<0.01).
- Compared to other sudden deafness types, total deafness with vertigo presented with more pronounced hypercoagulability (higher FIB and D-D, lower APTT) and the worst curative effect (63.6% ineffective rate).
Conclusions:
- Hypercoagulability and thrombosis are potential influencing factors in total sudden deafness.
- The hypercoagulable state is more severe in sudden deafness patients with total deafness and vertigo.
- These patients face the worst prognosis, necessitating targeted therapeutic interventions.
Abstract:
Objective:To analyze the coagulation status and prognosis of sudden deafness patients with total deafness accompanied by vertigo, and to provide basis for improving the treatment of this disease. Methods:From January 2017 to December 2020, 33 patients with total deafness and vertigo sudden deafness who were hospitalized in the Department of Otolaryngology Head and Neck Surgery, Hebei Provincial People's Hospital were selected as the research group. During the same period, 33 cases of low frequency type, full frequency type, total deafness and 26 cases of high frequency type were treated as control group.Thirty-three cases of inpatients without history of middle ear and inner ear diseases were treated as normal control group. The levels of fibrinogen（FIB）, D-Dimer（D-D）, Prothrombin Time（PT）, Activated Partial Thrombin Time（APTT） between the research group and the control group were analyzed, and the therapeutic effects of different types of sudden deafness patients were analyzed. Results:FIB and D-D of total deafness with vertigo were 2.50（2.11, 2.95）and 0.27（0.16, 0.51） respectively, which were higher than 2.31（1.92, 2.50） and 0.17（0.12, 0.21） of normal group. APTT was 25.2（23.1, 28.1）, lower than 27.3（26.4, 29.7） in the normal group, the differences were statistically significant（P<0.01）. ② FIB of total deafness with vertigo was 2.50（2.11, 2.95）, which was higher than that of low frequency group 2.37（1.81, 2.68）. D-D was 0.27（0.16, 0.51）, higher than low frequency group 0.16（0.12, 0.25）, high frequency group of 0.13（0.11, 0.23）, the whole frequency group 0.16（0.11, 0.28）, total of 0.18（1.45, 0.30）. APTT was 25.75±3.18/25.2（23.1, 28.1）, lower than 27.72±2.22 in low frequency group and 26.7（25.8, 28.7） in full frequency group, with statistical significance（P<0.05）. ③ The total deafness with vertigo group had the worst curative effect（ineffective rate was 63.6%）, and the low frequency group had the best curative effect（recovery rate was 75.8%）. The difference of curative effect among different types of sudden deafness groups was statistically significant（P<0.05）. Conclusion:Hypercoagulability and thrombosis may be one of the influencing factors of total sudden deafness. The hypercoagulable state of sudden deafness patients with total deafness and vertigo is more serious than that of total deafness and other types of sudden deafness, and the prognosis is the worst.
