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Genetic Engineering Systems to Study Human Viral Pathogens from the Coronaviridae Family.
S O Galkin1,2, A N Anisenko1,2,3, O A Shadrina2,3
1Bioengineering and Bioinformatics Department, Moscow State University, 119991 Moscow, Russia.
Molecular Biology
|February 23, 2022
Summary
This review summarizes genetic engineering systems for studying SARS-CoV-2 and other coronaviruses. It covers essential knowledge on coronavirus structure and life cycles for developing antiviral therapies.
Area of Science:
- Virology
- Molecular Biology
- Genetic Engineering
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, highlighted the need for advanced cellular systems.
- Studying coronaviruses requires effective methods for genome manipulation and inhibitor screening.
Purpose of the Study:
- To review existing genetic engineering systems for studying SARS-CoV-2 and other Coronaviridae.
- To provide foundational knowledge on coronavirus structure and life cycles.
Main Methods:
- Literature review of genetic engineering systems for coronaviruses.
- Compilation of data on SARS-CoV-2 and related viruses.
- Summary of fundamental coronavirus biology.
Main Results:
- Overview of various genetic engineering tools applicable to coronaviruses.
- Discussion of systems enabling viral genome manipulation.
- Identification of high-throughput screening platforms for antiviral discovery.
Conclusions:
- Effective genetic engineering systems are crucial for combating coronavirus infections.
- Understanding coronavirus structure and life cycles aids in developing novel therapeutic strategies.
- This review consolidates key information for researchers in the field.
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