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Related Concept Videos

Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Coats'-like Response Associated with Linear Scleroderma.

Hassan Behboudi1, Habib Zayeni2, Asghar Haji-Abbasi2

  • 1Eye Research Center, Department of Eye, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Journal of Ophthalmic & Vision Research
|February 23, 2022
PubMed
Summary
This summary is machine-generated.

Linear scleroderma, or en coup de sabre, can cause vision loss due to a Coats'-like response. Early detection and treatment with anti-VEGF agents and laser photocoagulation can significantly improve vision.

Keywords:
Coat's DiseaseCraniofacialEn Coup de SabreSclerodermaBevcizumab

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Area of Science:

  • Ophthalmology
  • Dermatology
  • Vascular Biology

Background:

  • Linear scleroderma, known as en coup de sabre, is a rare autoimmune condition affecting the skin and underlying tissues.
  • Ocular manifestations of en coup de sabre are uncommon but can lead to significant visual impairment.

Observation:

  • A 12-year-old boy with en coup de sabre experienced sudden, painless vision loss in the affected eye.
  • Ocular examination revealed vitreous hemorrhage, severe posterior pole exudation, and telangiectatic vessels.
  • Fundus fluorescein angiography confirmed a Coats e-like response with vascular abnormalities and leakage.

Findings:

  • The patient was treated with intravitreal bevacizumab and retinal photocoagulation.
  • After 12 months, there was significant resolution of macular exudation and visual improvement.

Implications:

  • This case highlights the importance of ophthalmologic evaluations in patients with en coup de sabre.
  • Intravitreal anti-VEGF therapy combined with laser photocoagulation shows promise for managing Coats e-like responses in this population.