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Related Concept Videos

Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

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The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
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Disorders of Erythrocytes01:27

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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
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On the other...
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Erythropoiesis01:14

Erythropoiesis

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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

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There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Related Experiment Video

Updated: Oct 2, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
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Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

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Erythrocytes Induce Vascular Dysfunction in COVID-19.

Ali Mahdi1, Aida Collado1, John Tengbom1

  • 1Division of Cardiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

JACC. Basic to Translational Science
|February 23, 2022
PubMed
Summary

Red blood cells play a key role in COVID-19 vascular dysfunction. Targeting reactive oxygen species or arginase 1 in red blood cells may improve endothelial function and alleviate complications.

Keywords:
ACh, acetylcholineC19-RBC, red blood cell from patients with COVID-19COVID-19EDR, endothelium-dependent relaxationEIR, endothelium-independent relaxationH-RBC, red blood cell from healthy subjectsHNE, hydroxynonenalIFN, interferonRBC, red blood cellRHI, reactive hyperemia indexROS, reactive oxygen speciesSNP, sodium nitroprussideTNF, tumor necrosis factorarginaseendothelial dysfunctionnitric oxidereactive oxygen speciesred blood cells

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Area of Science:

  • Cardiovascular Research
  • Hematology
  • Infectious Diseases

Background:

  • Mechanisms of COVID-19 cardiovascular complications are not fully understood.
  • Endothelial dysfunction is a significant concern in COVID-19 patients.

Purpose of the Study:

  • To identify novel mechanisms of COVID-19-associated vascular dysfunction.
  • To investigate the role of red blood cells in COVID-19 vascular complications.

Main Methods:

  • In vivo assessment of endothelial function in COVID-19 patients.
  • Investigated the impact of targeting reactive oxygen species and arginase 1.

Main Results:

  • Demonstrated profound and persistent endothelial dysfunction in COVID-19 patients.
  • Identified red blood cells as a key driver of this vascular dysfunction.
  • Showed that targeting reactive oxygen species or arginase 1 ameliorates red blood cell-mediated vascular dysfunction.

Conclusions:

  • Red blood cells contribute significantly to COVID-19-related vascular dysfunction.
  • Restoring redox balance in red blood cells shows therapeutic potential for COVID-19 vascular complications.