Related Experiment Video
Updated: Oct 2, 2025
09:57
Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
Published on: August 12, 2019
9.8K
Correlation between Increased Monocyte Chemotactic Protein 1 Level and Lung Function in Patients with Asthma
Weifeng Zong1, Yuqing Mo2, Yuxia Liang3,4
1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
International Archives of Allergy and Immunology
|February 23, 2022
Summary
Monocyte chemotactic protein 1 (MCP1) levels in sputum and serum are elevated in asthma patients and correlate with reduced lung function. Combining MCP1 levels with Th2 inflammation identifies a new asthma phenotype for predicting lung function and treatment response.
Area of Science:
- Allergy and Immunology
- Respiratory Medicine
- Molecular Biology
Background:
- Monocyte chemotactic protein 1 (MCP1) expression is altered in allergic asthma.
- The relationship between induced sputum MCP1 levels and asthma clinical features is not well understood.
Purpose of the Study:
- To investigate the correlation between MCP1 protein expression in induced sputum and Th2 inflammation in asthma.
- To explore the association of MCP1 levels with asthma clinical features and lung function.
Main Methods:
- MCP1 protein levels in induced sputum and serum were measured using ELISA in asthma patients.
- Correlations with Th2 inflammation, lung function (FEV1/FVC%), and airway hyperresponsiveness (PC-20) were analyzed.
- The impact of inhaled corticosteroids (ICSs) on MCP1 levels was evaluated.
Main Results:
- MCP1 levels were significantly increased in induced sputum and serum of asthma patients.
- Elevated MCP1 levels negatively correlated with FEV1/FVC% and PC-20, indicating poorer lung function and higher airway hyperresponsiveness.
- A subgroup with low Th2 inflammation and high MCP1 (Th2Low MCP1Hi) exhibited the worst lung function and highest airway hyperresponsiveness.
- MCP1 levels significantly decreased after 4 weeks of ICS treatment.
Conclusions:
- Increased MCP1 levels in sputum and serum are associated with asthma severity.
- The combination of MCP1 levels and Th2 inflammation defines a novel asthma phenotype.
- This new phenotype can predict lung function and response to ICS treatment in asthma patients.
Related Concept Videos
01:26Asthma-II: Pathophysiology and Classification
3.2K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.2K
01:19Antiasthma Drugs: Leukotriene Modifiers
642
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
642
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
3.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
3.2K
01:20Asthma: Pathogenesis and Management
797
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
797
01:30Asthma-IV: Diagnostic and Management
2.7K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.7K
01:24Asthma-III: Symptoms and Complications
2.7K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.7K