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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
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Taking Microbiota into Consideration in Mesenchymal Stem Cell Research.

H Tu1, E Xiao2, O Liu1

  • 1Hunan Key Laboratory of Oral Health Research and Human 3D Printing Engineering Research Central of Oral Care and Hunan Clinical Research Center of Oral Major Diseases and Oral Health and Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha City, Hunan Province, P.R. China.

Journal of Dental Research
|February 24, 2022
PubMed
Summary

The human microbiota influences mesenchymal stem cells (MSCs) functions, impacting their use in regenerative medicine. Understanding this interaction is key to improving stem cell therapies.

Keywords:
bacteriahost pathogen interactionsmicrobiomeregenerative medicinestem cell therapystem cells

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Area of Science:

  • Regenerative Medicine
  • Microbiology
  • Stem Cell Biology

Background:

  • Mesenchymal stem cells (MSCs) show therapeutic potential but clinical efficacy is limited by modulating factors.
  • The human microbiota is increasingly recognized as a significant modulator of MSC functions.

Purpose of the Study:

  • To highlight the role of microbiota in altering MSC functions, including self-renewal, differentiation, and immunomodulation.
  • To review current research on microbiota's effects in stem cell therapy and discuss underlying mechanisms.

Main Methods:

  • Literature review of clinical trials and model research.
  • Analysis of omics approaches and verification experiments elucidating microbiota-MSCs interplay.

Main Results:

  • Microbiota significantly modulates MSC self-renewal, differentiation potential, and immunomodulatory capacity.
  • Synergistic and antagonistic effects of microbiota on stem cell therapy outcomes are observed.

Conclusions:

  • The interplay between microbiota and MSCs is crucial for regenerative medicine.
  • Further research, particularly in the oral field, is needed to optimize MSC-based therapies by considering microbial interactions.