Multi-Task Deep Learning Approach for Simultaneous Objective Response Prediction and Tumor Segmentation in HCC...

This study aimed to develop a deep learning-based model to simultaneously perform the objective response (OR) and tumor segmentation for hepatocellular carcinoma (HCC) patients who underwent transarterial chemoembolization (TACE) treatment. A total of 248 patients from two hospitals were retrospectively included and divided into the training, internal validation, and external testing cohort. A network consisting of an encoder pathway, a prediction pathway, and a segmentation pathway was developed, and named multi-DL (multi-task deep learning), using contrast-enhanced CT images as input. We compared multi-DL with other deep learning-based OR prediction and tumor segmentation methods to explore the incremental value of introducing the interconnected task into a unified network. Additionally, the clinical model was developed using multivariate logistic regression to predict OR. Results showed that multi-DL could achieve the highest AUC of 0.871 in OR prediction and the highest dice coefficient of 73.6% in tumor segmentation. Furthermore, multi-DL can successfully perform the risk stratification that the low-risk and high-risk patients showed a significant difference in survival (p = 0.006). In conclusion, the proposed method may provide a useful tool for therapeutic regime selection in clinical practice.