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Differences of Sex Development: What Neonatologists Need to Know
Natalie G Allen1, Kanthi Bangalore Krishna1, Peter A Lee1
1Division of Endocrinology and Diabetes, Department of Pediatrics, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Clinics in Perinatology
|February 25, 2022
Summary
Neonatologists encounter differences of sex development (DSD) in newborns. This article guides initial DSD patient evaluation, terminology, and care controversies for healthcare providers.
Area of Science:
- Pediatrics
- Genetics
- Endocrinology
Background:
- Differences of sex development (DSD) are rare conditions affecting typical male or female development.
- Neonatologists are frequently the first healthcare professionals to assess newborns with DSD.
- Familiarity with DSD management is crucial for neonatologists.
Purpose of the Study:
- To define Differences of Sex Development (DSD).
- To outline the initial diagnostic workup for neonates with DSD.
- To discuss current terminology and controversies in DSD care.
Main Methods:
- Literature review on DSD definitions and diagnostic approaches.
- Analysis of current terminology and ethical considerations in DSD management.
- Discussion of controversies in the clinical approach to DSD.
Main Results:
- Provides a clear definition of DSD.
- Details the essential components of initial patient workup.
- Highlights evolving terminology and ongoing debates in DSD care.
Conclusions:
- Neonatologists require a foundational understanding of DSD.
- Standardized initial evaluation and clear communication are vital.
- Addressing care controversies requires ongoing discussion and research.
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