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Correction: Pramesthi et al. Evaluating the Impact of Indonesia's National School Feeding Program (ProGAS) on Children's Nutrition and Learning Environment: A Mixed-Methods Approach. <i>Nutrients</i> 2025, <i>17</i>, 3575.

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Reference Ranges of Glycemic Variability in Infants after Surgery-A Prospective Cohort Study.

Halla Kaminska1, Pawel Wieczorek2, Grzegorz Zalewski3

  • 1Department of Children's Diabetology, School of Medicine in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.

Nutrients
|February 26, 2022
PubMed
Summary
This summary is machine-generated.

Continuous glucose monitoring (CGM) in non-diabetic infants post-cardiac surgery revealed high hyperglycemia risk on day one. New reference ranges are proposed for pediatric intensive care unit (PICU) patients to manage glycemic variability.

Keywords:
congenitalglycemic controlheart defectsintensive care unitspediatricpostoperative carereference valuesthoracic surgery

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Area of Science:

  • Pediatric Intensive Care
  • Endocrinology
  • Cardiovascular Surgery

Background:

  • Glycemic variability is critical in non-diabetic infants post-cardiac surgery.
  • Current glucose monitoring ranges may not suit critically ill pediatric patients.

Purpose of the Study:

  • Establish reference ranges for glycemic variability indices in infants undergoing cardiac surgery.
  • Utilize continuous glucose monitoring (CGM) data to define these ranges.

Main Methods:

  • Prospective cohort intervention study in a pediatric intensive care unit (PICU).
  • Continuous glucose monitoring (CGM) applied to 65 non-diabetic infants (0-12 months) post-cardiac surgery.
  • Analysis of 13 glycemic variability indices over the first three postoperative days.

Main Results:

  • Hyperglycemia was frequent on the first postoperative day (40%), decreasing thereafter.
  • Hypoglycemia also occurred, increasing from 5% on day one to 43% by day three.
  • Distinct glucose level differences between the acute (day 1) and steady states (days 2-3) necessitated separate reference ranges.

Conclusions:

  • Real-time CGM (rt-CGM) highlights significant glycemic dysregulation in infants post-cardiac surgery, particularly hyperglycemia early on.
  • Proposed reference ranges for individual and mean daily glucose levels differ between acute and steady states.
  • CGM use in PICU settings is recommended, but tailored reference ranges are essential for accurate interpretation in non-diabetic pediatric surgical patients.