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Testosterone Replacement Therapy in Hypogonadal Men.

Christina Wang1, Ronald S Swerdloff2

  • 1Division of Endocrinology, Clinical and Translational Science Institute, The Lundquist Institute at Harbor-UCLA Medical Center, Harbor-UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA.

Endocrinology and Metabolism Clinics of North America
|February 26, 2022
PubMed
Summary
This summary is machine-generated.

Testosterone replacement therapy effectively restores normal levels and alleviates hypogonadal symptoms. Physician and patient choice guides method selection, with fertility considerations addressed by specific treatments.

Keywords:
Endogenous testosterone stimulatorsImplantsIntramuscular injectionsModified androgensOral capsulesSelective androgen receptor modulatorsTransdermal gels

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Area of Science:

  • Endocrinology
  • Men's Health
  • Pharmacology

Background:

  • Hypogonadism is characterized by low serum testosterone levels.
  • Symptoms include fatigue, decreased libido, and mood disturbances.
  • Testosterone replacement therapy (TRT) is a common treatment.

Purpose of the Study:

  • To review approved testosterone replacement methods.
  • To discuss symptom relief and serum concentration restoration.
  • To outline considerations for fertility preservation during TRT.

Main Methods:

  • Review of approved testosterone formulations.
  • Analysis of clinical outcomes and patient preferences.
  • Discussion of fertility-sparing adjunct therapies.

Main Results:

  • Approved TRT methods restore normal testosterone levels and relieve hypogonadal symptoms.
  • Method selection is patient- and physician-guided.
  • Hepatotoxic androgens should be avoided.
  • Fertility can be managed with specific agents during TRT.

Conclusions:

  • TRT is effective for hypogonadal men.
  • Personalized treatment selection is crucial.
  • Fertility concerns require tailored management strategies.