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Updated: Oct 2, 2025
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Published on: March 12, 2019
External validation of four Pancreatic Fistula Risk Score models in the Deep South US: Do racial disparities affect
Conrad K Blunck1, Selwyn M Vickers1, Thomas N Wang1
1University of Alabama at Birmingham School of Medicine, 1670 University Blvd, Birmingham, AL, 35233, USA.
Background:
Fistula Risk Score (FRS) models often lack adequate discrimination for clinically relevant postoperative pancreatic fistula (CR-POPF) on external validation. We tested four FRS models in the Deep South United States and sought to determine if CR-POPF discrimination was affected by racial disparities.
Methods:
A single-institution retrospective cohort study of patients who underwent pancreatoduodenectomies between 2013 and 2019 was performed. FRS discrimination for CR-POPF was assessed using ROC curves for both the entire patient population, and for Black vs White patients.
Results:
The Alternative FRS maintains adequate CR-POPF discrimination when considering the patient population as a whole, but inadequately predicts CR-POPF when applied to the Black patient population. The Sun-FRS provides adequate CR-POPF discrimination for Black patients when considering risk grade. Only soft pancreatic gland texture and small duct size were significantly associated with CR-POPF in this patient population.
Discussion:
Institutions should assess their preferred FRS model to determine if it provides adequate CR-POPF discrimination among a racially diverse patient population. Further studies are needed to determine how racial disparities influence CR-POPF prediction to better guide postoperative management.
