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Axillary Adenopathy Secondary to SARS-CoV-2 Vaccination: a Case Report
1Division of Infectious Diseases, Department of Medicine, UC Davis School of Medicine, Sacramento, CA USA.
SN Comprehensive Clinical Medicine
|February 28, 2022
Summary
COVID-19 mRNA vaccines are safe and effective. Axillary lymphadenopathy can occur after vaccination, particularly with the Moderna vaccine, but it is temporary and resolves on its own.
Area of Science:
- Immunology
- Radiology
- Infectious Diseases
Background:
- SARS-CoV-2 mRNA vaccines (Pfizer-BioNTech and Moderna) are crucial for preventing COVID-19.
- Local reactions are common post-vaccination.
- Axillary lymphadenopathy is a reported side effect that can mimic other conditions.
Observation:
- A 58-year-old female with latent tuberculosis presented with a pulmonary nodule.
- FDG PET/CT revealed highly avid left axillary lymph nodes.
- The patient had recently received the mRNA-1273 (Moderna) COVID-19 vaccine in her left arm.
Findings:
- Axillary lymphadenopathy following mRNA vaccination is a recognized phenomenon.
- It appears more prevalent with the Moderna vaccine compared to Pfizer-BioNTech.
- Lymphadenopathy is more common in younger adults (18-64) and after the second vaccine dose.
Implications:
- Vaccination status should be considered in the differential diagnosis of axillary lymphadenopathy.
- Identifying vaccination as the cause can prevent unnecessary investigations, procedures, and patient anxiety.
- This finding aids clinicians in accurate diagnosis and patient management.
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