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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

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Directing Multivalent Aptamer-Receptor Binding on the Cell Surface with Programmable Atom-Like Nanoparticles.

Linjie Guo^1,2,3, Yueyue Zhang⁴, Yue Wang^1,2

¹Division of Physical Biology Department, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.

Angewandte Chemie (International Ed. in English)

|February 28, 2022

Summary

This summary is machine-generated.

Researchers developed programmable atom-like nanoparticles (aptPANs) to control how aptamers bind to cell receptors. This innovation allows for precise control over multivalent interactions, enhancing tumor cell targeting and inhibiting cell growth.

Keywords:

Atom-Like Nanoparticles DNA Frameworks Multivalent Cell Aptamers Stereoisomers

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Area of Science:

Biomolecular interactions
Nanotechnology
Synthetic biology

Background:

Multivalent biomolecular interactions are vital in biological processes and diseases.
Current synthetic systems struggle with programmable control over interaction directionality.

Purpose of the Study:

To design programmable atom-like nanoparticles (aptPANs) for directed multivalent aptamer-receptor binding.
To enable precise control over valence and directionality in synthetic molecular systems.

Main Methods:

Utilizing tetrahedral DNA frameworks to position aptamer motifs.
Creating aptPANs with defined aptamer copy numbers and varied directionality.
Assessing aptPAN adaptability to cell surface receptor distribution.

Main Results:

Achieved programmable orthogonal directionality in multivalent ligand-receptor systems.
Demonstrated high-affinity tumor cell binding using linear aptPAN oligomers, with a 13-fold improvement over free aptamers.
Observed approximately 50% suppression of tumor cell growth.

Conclusions:

Programmable aptPANs offer a novel approach to engineer directional multivalent interactions.
The developed system enhances targeting specificity and biological efficacy in cellular contexts.
This technology holds potential for advanced therapeutic and diagnostic applications.