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Sensor System Based on a Piezoelectric Resonator with a Lateral Electric Field for Virus Diagnostics
Olga I Guliy1, Boris D Zaitsev2, Alexander P Semyonov2
1Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Center of the Russian Academy of Sciences, Saratov, Russia.
Ultrasound in Medicine & Biology
|March 2, 2022
Summary
This study presents a novel piezoelectric resonator sensor for real-time virus detection in liquid. Specific antibodies binding to viruses cause measurable impedance changes, enabling accurate identification.
Area of Science:
- Biomedical Engineering
- Biosensing Technology
- Virology
Background:
- Current virus detection methods can be time-consuming and require sample preparation.
- There is a need for rapid, in-situ detection of viruses in their native environment.
Purpose of the Study:
- To develop and validate a piezoelectric resonator-based sensor system for real-time virus detection.
- To assess the sensor's specificity and sensitivity using a model virus and antibodies.
Main Methods:
- Utilizing a piezoelectric resonator operating at 6-7 MHz with a lateral electric field.
- Employing specific antibodies to capture a transmissible pig gastroenteritis virus.
- Monitoring changes in the electrical impedance (real and imaginary parts) of the resonator upon virus-antibody interaction.
Main Results:
- Significant changes in electrical impedance were observed when specific antibodies bound to the target virus in suspension.
- No significant impedance changes occurred with non-specific antibodies, confirming sensor specificity.
- The system demonstrated successful virus detection in the presence of foreign viral particles.
Conclusions:
- The piezoelectric resonator sensor system offers a viable method for in-situ, real-time virus detection in liquid phases.
- Changes in electrical impedance serve as a reliable analytical signal for virus identification.
- This technology holds potential for rapid diagnostics in various virological applications.
