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Updated: Oct 1, 2025
Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
Electrochemically produced local pH changes stimulating (bio)molecule release from pH-switchable
Ronaldo Badenhorst1, Vasantha Krishna Kadambar1, Madhura Bellare1
1Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA. osmutok@clarkson.edu.
Abstract:
Immobilized avidin-biotin complexes were used to release biotinylated (bio)molecules upon producing local pH changes near an electrode surface by electrochemical reactions. The nitro-avidin complex with biotin was dissociated by increasing local pH with electrochemical O2 reduction. The avidin complex with iminobiotin was split by decreasing local pH with electrochemical oxidation of ascorbate. Both studied systems were releasing molecule cargo species in response to small electrical potentials (-0.4 V or 0.2 V for the O2 reduction or ascorbate oxidation, respectively) applied on the modified electrodes.
