A common evolutionary origin reveals fundamental principles of protein insertases
F-Nora Vögtle1,2,3, Hans-Georg Koch4, Chris Meisinger3,4,5
1Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.
Plos Biology
|March 2, 2022
Abstract:
Membrane proteins require protein machineries to insert their hydrophobic transmembrane domains (TMDs) into the lipid bilayer. A functional analysis of protein insertases in this issue of PLOS Biology reveals that the fundamental mechanism of membrane protein insertion is universally conserved.
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