Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Decomposing the modulation of interactions between neuronal populations.

bioRxiv : the preprint server for biology·2026

Same author

The multiple scales of astrocytic functional units.

Nature neuroscience·2026

Same author

Contribution of spike timing to the neural code: from fast to slow timescales.

Biological cybernetics·2026

Same author

Next-generation multicolor indicators for in vivo imaging of norepinephrine.

Nature methods·2026

Same author

Attractor dynamics of a whole-cortex network model predicts emergence and structure of fMRI co-activation patterns in the mouse brain.

PLoS computational biology·2026

Same author

Axon initial segment dynamics during associative fear learning.

Nature neuroscience·2025

Same journal

Towards globally equitable bioinformatics adoption.

PLoS biology·2026

Same journal

The human claustrum supports cognitive networks for externally and internally driven task demands.

PLoS biology·2026

Same journal

Unusual decay: Recombination loss leads to splicing errors in green algae.

PLoS biology·2026

Same journal

Angptl5 restricts primitive hematopoiesis by promoting retinoic acid signaling in zebrafish.

PLoS biology·2026

Same journal

Engineered bipaternal mice reveal the consequences of life without a maternal genomic contribution.

PLoS biology·2026

Same journal

Multiple adhesion molecules act together in oligodendrocyte-mediated axonal selection and myelin formation.

PLoS biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 1, 2025

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Published on: November 26, 2012

Complementary encoding of spatial information in hippocampal astrocytes.

Sebastiano Curreli^1,2, Jacopo Bonato^2,3,4, Sara Romanzi^1,2,5

¹Optical Approaches to Brain Function Laboratory, Istituto Italiano di Tecnologia, Genova, Italy.

|March 3, 2022

Summary

This summary is machine-generated.

Astrocytes, brain cells previously overlooked in information coding, actively encode spatial navigation data. Their signals complement neuronal activity, enhancing brain circuit spatial decoding.

More Related Videos

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Published on: March 31, 2022

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

Related Experiment Videos

Last Updated: Oct 1, 2025

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Published on: November 26, 2012

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

Published on: March 31, 2022

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

Area of Science:

Neuroscience
Neurobiology
Astrocyte Biology

Background:

Astrocytic calcium dynamics are known to influence neuronal activity.
Current models often overlook astrocytes in neural information coding due to assumed signal mirroring.
The specific contribution of astrocytes to spatial information encoding remains unclear.

Purpose of the Study:

To investigate whether astrocytes encode spatial information independently of visual cues.
To determine if astrocytic calcium signals are complementary or synergistic to neuronal signals.
To assess the impact of incorporating astrocytic signals on spatial decoding accuracy.

Main Methods:

Simultaneous two-photon calcium imaging in hippocampal astrocytes and neurons of mice.
Mice navigated a virtual environment during imaging.
Analysis of astrocytic calcium signals for spatial information content and topographical organization.

Main Results:

Astrocytic calcium signals were found to encode spatial information not explained by visual cues alone.
Spatial information in astrocytes was localized to topographically organized subregions.
Astrocytic spatial encoding was complementary and synergistic to neuronal encoding, improving overall spatial decoding.

Conclusions:

Astrocytes play a significant role in encoding spatial information within brain circuits.
Localized astrocytic calcium signals may regulate synaptic clusters, influencing population coding.
These findings challenge existing models and highlight the dynamic role of astrocytes in cognitive functions like navigation.