Liver transplantation at UCLA. Program development, organization, initiation, and early results

Area of Science:

• Hepatology
• Surgical Sciences
• Transplantation Medicine

Background:

• Liver transplantation is a complex procedure requiring extensive resources.
• Successful programs necessitate a multidisciplinary approach and specialized training.
• Tertiary referral centers are essential for developing and sustaining liver transplant initiatives.

Purpose of the Study:

• To outline the essential components for establishing a successful liver transplant program.
• To report the initial outcomes of the UCLA liver transplant program.

Main Methods:

• A multidisciplinary team approach was implemented.
• Comprehensive training was conducted in animal laboratories and at an established transplant center.
• Significant institutional commitment across various departments was secured.

Main Results:

• UCLA performed 62 liver transplants in 50 patients within the first two years.
• The overall survival rate was 72%, with no operative deaths.
• 34 of 36 surviving patients returned to productive lives post-transplant.

Conclusions:

• A well-planned, multidisciplinary approach enables the successful establishment of liver transplant programs.
• The initial outcomes at UCLA demonstrate the feasibility and effectiveness of their liver transplant program.
• Liver transplantation can significantly improve patient quality of life and long-term survival.