Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

29.7K
Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
29.7K
Diffusion01:21

Diffusion

5.5K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
5.5K
Stress-Strain Diagram - Brittle Materials01:24

Stress-Strain Diagram - Brittle Materials

2.9K
Brittle materials, including glass, cast iron, and stone, exhibit unique characteristics. They fracture without considerable change in their elongation rate, indicating that their breaking and ultimate strength are equivalent. Such materials also show lower strain levels at the point of rupture. The failure in brittle materials predominantly results from normal stresses, as evidenced by the rupture created along a surface perpendicular to the applied load. These materials do not display...
2.9K
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

857
Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
857
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

493
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
493
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.7K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaporative coupled with antisolvent crystallization for additive manufacturing of personalized solid dosage forms.

International journal of pharmaceutics·2026
Same author

Non-destructive pipeline for analysis of crystalline solid dispersions.

International journal of pharmaceutics·2026
Same author

Revisiting the dihaloelimination potential of <i>Dehalococcoides</i> revealed by genomic and proteomic analyses.

Applied and environmental microbiology·2026
Same author

Analysis of Genetic Characteristics, Biofilm Formation Ability, and Mortality Risk Factors in Patients Infected with Carbapenem-Resistant <i>Acinetobacter baumannii</i>.

Infection and drug resistance·2026
Same author

Effect of Cooling Methods on CFRP-Concrete Bond Behavior After High-Temperature Exposure: An Experimental Study.

Polymers·2026
Same author

Demonstration of partially transparent thick metallic sodium in the vacuum ultraviolet spectral range: comment.

Optics express·2026
Same journal

Erratum: Bacterial Turbulence at Compressible Fluid Interfaces [Phys. Rev. Lett. 136, 138301 (2026)].

Physical review letters·2026
Same journal

Unveiling Light-Quark Yukawa Flavor Structure via Dihadron Fragmentation at Lepton Colliders.

Physical review letters·2026
Same journal

Adaptable Route to Fast Coherent State Transport via Bang-Bang-Bang Protocols.

Physical review letters·2026
Same journal

Topological Transition and Emergence of Elasticity of Dislocation in Skyrmion Lattice: Beyond Kittel's Magnetic-Polar Analogy.

Physical review letters·2026
Same journal

Pound-Drever-Hall Method for Superconducting-Qubit Readout.

Physical review letters·2026
Same journal

Coupling a ^{73}Ge Nuclear Spin to an Electrostatically Defined Quantum Dot in Silicon.

Physical review letters·2026
See all related articles

Related Experiment Video

Updated: Oct 1, 2025

Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion
06:48

Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion

Published on: May 9, 2025

653

Surface Diffusion Is Controlled by Bulk Fragility across All Glass Types.

Yuhui Li1, Ajay Annamareddy2, Dane Morgan2

  • 1School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.

Physical Review Letters
|March 4, 2022
PubMed
Summary
This summary is machine-generated.

Surface diffusion in glasses is strongly linked to bulk fragility. Fragile glasses exhibit much faster surface diffusion than bulk diffusion, unlike strong glasses like SiO2.

More Related Videos

Cooling Rate Dependent Ellipsometry Measurements to Determine the Dynamics of Thin Glassy Films
09:32

Cooling Rate Dependent Ellipsometry Measurements to Determine the Dynamics of Thin Glassy Films

Published on: January 26, 2016

8.3K
Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
11:34

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

10.4K

Related Experiment Videos

Last Updated: Oct 1, 2025

Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion
06:48

Fluid-cell Raman Spectroscopy for operando Studies of Reaction and Transport Phenomena during Silicate Glass Corrosion

Published on: May 9, 2025

653
Cooling Rate Dependent Ellipsometry Measurements to Determine the Dynamics of Thin Glassy Films
09:32

Cooling Rate Dependent Ellipsometry Measurements to Determine the Dynamics of Thin Glassy Films

Published on: January 26, 2016

8.3K
Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
11:34

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

10.4K

Area of Science:

  • Materials Science
  • Physical Chemistry
  • Condensed Matter Physics

Background:

  • Surface diffusion differs significantly from bulk diffusion in various glass systems.
  • The degree of enhancement in surface diffusion varies considerably across different types of glasses.

Purpose of the Study:

  • To investigate the relationship between surface diffusion enhancement and bulk fragility in glasses.
  • To understand how glass dynamics influence surface properties and behavior.

Main Methods:

  • Analysis of surface diffusion rates in diverse glass systems.
  • Correlation of diffusion data with bulk fragility measurements.
  • Comparative study across molecular, metallic, and inorganic glasses.

Main Results:

  • Surface diffusion can be up to 10^8 times faster than bulk diffusion in fragile molecular glasses at the glass transition temperature.
  • In strong glasses like SiO2, the surface diffusion enhancement is only a factor of 10.
  • Intermediate fragility systems, including metallic glasses and amorphous selenium/silicon, show varying degrees of enhancement.

Conclusions:

  • Bulk fragility is a key predictor of surface diffusion enhancement in glasses.
  • Stronger liquids exhibit greater resistance to dynamic excitation from bulk to surface.
  • Findings enable predictions for surface diffusion, crystallization, and stable glass formation via vapor deposition.