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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Physiological relevance of proton-activated GPCRs

Pedro H Imenez Silva1,2, Carsten A Wagner3,4

  • 1Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland. pedrohenrique.imenezsilva@uzh.ch.

Pflugers Archiv : European Journal of Physiology
|March 5, 2022
PubMed
Summary

This review covers proton-activated G protein-coupled receptors (GPCRs) like GPR4, TDAG8, and OGR1, which sense extracellular pH changes. These receptors play key roles in physiological functions and are implicated in various diseases, offering potential therapeutic targets.

Keywords:
Acid–base balanceBoneCell signalingInflammationKidneyRespirationpH sensing

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