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Related Concept Videos

Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

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Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
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Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
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Updated: Oct 1, 2025

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
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Targeting foodborne pathogens via surface-functionalized nano-antimicrobials.

Akbar Bahrami1, Rana Delshadi2, Ilaria Cacciotti3

  • 1Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC 28081, USA.

Advances in Colloid and Interface Science
|March 6, 2022
PubMed
Summary
This summary is machine-generated.

Functional nanoparticles enhance antimicrobial delivery against foodborne pathogens by overcoming bacterial defenses and improving targeted delivery. Surface modification of nanocarriers boosts their efficacy and circulation time for better therapeutic outcomes.

Keywords:
AntimicrobialsFoodborne pathogensNanocarriersSurface-functionalized

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Area of Science:

  • Nanotechnology
  • Antimicrobial Agents
  • Foodborne Pathogens
  • Drug Delivery Systems

Background:

  • Antimicrobial nanocarriers are developed using non-toxic nanoparticles loaded with antibiotics or bioactive compounds to combat foodborne pathogens.
  • Challenges include bacterial intracellular localization and persistence within phagocytic cells, limiting conventional antimicrobial efficacy.
  • Nanocarrier systems offer protection, controlled release, and enhanced activity but face barriers to optimal function.

Purpose of the Study:

  • To review techniques for surface functionalization of antimicrobial-loaded nanocarriers.
  • To explore the potential of functional nanoparticles in enhancing antimicrobial performance against foodborne pathogens.
  • To highlight strategies for overcoming barriers like intracellular bacterial infections and improving targeted delivery.

Main Methods:

  • Review of scientific literature on nanocarrier surface modification techniques.
  • Analysis of passive and active modification methods for nanocarrier functionalization.
  • Examination of functional agents including peptides, ligands, antibodies, and enzymes for targeted delivery.

Main Results:

  • Surface functionalization protects nanocarriers from rapid clearance, extending circulation time.
  • Targeted delivery strategies significantly increase nanocarrier uptake by host cells.
  • Functionalized nanocarriers demonstrate improved efficacy against intracellular and persistent foodborne pathogens.

Conclusions:

  • Surface functionalization is a key strategy to enhance the performance of antimicrobial nanocarriers.
  • Targeted delivery via functionalized nanoparticles offers a promising approach to combat challenging foodborne pathogens.
  • Further research into advanced functionalization techniques can optimize nanocarrier-based antimicrobial therapies.