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Modality specific U-Net variants for biomedical image segmentation: a survey
Narinder Singh Punn1, Sonali Agarwal1
1IIIT Allahabad, Prayagraj, 211015 India.
Summary
U-Net architectures excel in biomedical image segmentation for computer-aided diagnosis. This review analyzes U-Net variants, their applications in disease detection, and future research directions.
Area of Science:
- Deep learning
- Medical image analysis
- Biomedical engineering
Background:
- U-Net architectures are pivotal in biomedical image segmentation for automated region identification.
- Deep learning models like CNNs, ResNets, and GANs underpin these advancements.
- U-Net based approaches achieve state-of-the-art performance in computer-aided diagnosis systems.
Purpose of the Study:
- To present the success of U-Net architectures in biomedical image segmentation.
- To comprehensively analyze U-Net variants through inter-modality and intra-modality categorization.
- To highlight U-Net's contribution to COVID-19 diagnosis and identify future research directions.
Main Methods:
- Describing the U-Net framework.
- Categorizing U-Net variants based on inter-modality and intra-modality analysis.
- Reviewing applications in various medical imaging modalities and diseases (e.g., brain tumors, lung cancer, COVID-19).
Main Results:
- U-Net variants demonstrate significant success in automated biomedical image segmentation.
- Analysis provides insights into challenges and solutions across different imaging modalities.
- U-Net frameworks have shown notable contributions in diagnosing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Conclusions:
- U-Net based approaches are highly effective for computer-aided diagnosis and disease detection.
- Further research into U-Net variants can enhance biomedical image segmentation accuracy and clinical utility.
- Addressing segmentation challenges will unlock new avenues for deep learning in medical imaging.

