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Updated: Oct 1, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
Hospitalization requiring intensive care unit due to SARS-CoV-2 infection correlated with IgM depression and IgG
Sara Tamizuddin1, Jason Cham1,2, Yasamin Ghiasi1
1Department of Medicine, Scripps Clinic/Scripps Green Hospital, La Jolla, CA 92037, USA.
Aim:
This study investigated the humoral response against SARS-CoV-2 in patients needing intensive care unit (ICU) care compared with those on general medicine wards.
Materials & Methods:
The authors retrospectively reviewed 113 hospitalized patients with COVID-19. They assessed antibody response against five SARS-CoV-2 epitopes at 6-14 days post symptom onset in these patients.
Results:
Patients with ICU admissions had decreased anti-nucleocapsid immunoglobulin (Ig)M and increased anti-spike IgG compared with patients not requiring the ICU. IgG levels were positively correlated with length of stay.
Conclusion:
Higher levels of IgG against the spike protein correlate with COVID-19 disease severity and length of stay in hospitalized patients. This adds to the knowledge of biochemical response to clinical disease and may help predict ICU needs.
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